β2-AR coding SNPs and hypertension
| Amino Acid Change | Genetic Association Noted | Reference |
|---|---|---|
| Arg16Gly | Gly16 associated with hypertension (African Caribbean, 136 hypertensive and 81 normotensive) | Kotanko et al., 1997 |
| Arg16Gly | Arg16 associated with hypertensive family-history; risk analysis implicated Arg16 (23 hypertensive and 22 normotensive families) | Timmermann et al., 1998 |
| Arg16Gly | Gly16 associated with increase in BP (57 normotensive Austrian Caucasians) | Gratze et al., 1999 |
| Arg16Gly, Gln27Glu | No association with hypertension (African American, n = 283, or Caucasian, n = 380) | Xie et al., 2000 |
| Arg16Gly | No association with hypertension or hemodynamic measures (African-American or Caucasian, 243 subjects) | Herrmann et al., 2000 |
| Arg16Gly, Gln27Glu | Gly16, Glu27 small, but significant, association with hypertension and BP (∼300 families) | Bray et al., 2000 |
| Arg16Gly | Arg16 associated with higher BP and greater risk of hypertension (166 pairs of German twins: 100 mono- and 66 di-zygotic twins) | Busjahn et al., 2000 |
| Arg16Gly | Gly16 significantly associated with essential hypertension (Chinese, >800) | Ranade et al., 2001 |
| Arg16Gly, Gln27Glu, Thr164Ile, haplotypes | No association with hypertension, SBP, or DBP (Polish pedigree, 638 subjects) | Tomaszewski et al., 2002 |
| Arg16Gly, Gln27Glu, haplotypes | Association of BP with various genotypes in younger subjects only (aged <50) (571 subjects, random sample general population) | Castellano et al., 2003 |
| Arg16Gly, Gln27Glu | No association with hypertension (808 African American and 4441 Caucasians) | Heckbert et al., 2003 |
SBP, systolic blood pressure; DBP, diastolic blood pressure.