Class | Gene | Organism | Response Element | Receptor | Reference |
---|---|---|---|---|---|
Drug oxidation (phase I) | Cyp1a1 | Mouse | ? | CAR | Maglich et al., 2002 |
CYP1a2 | Mouse | ? | CAR | Maglich et al., 2002 | |
CYP2a4 | Mouse | ? | CAR | Maglich et al., 2002 | |
CYP2B1/2 | Rat | DR-4 | CAR, PXR | Sueyoshi and Negishi, 2001 | |
CYP2B6 | Human | DR-4 | CAR, PXR | Sueyoshi and Negishi, 2001 | |
CYP2b10 | Mouse | DR-4 | CAR, PXR | Sueyoshi and Negishi, 2001 | |
CYP2C8 | Human | DR-4 | PXR | Ferguson et al., 2002b | |
CYP2C9 | Human | DR-4 | CAR, PXR | Gerbal-Chaloin et al., 2002 | |
CYP2C19 | Human | DR-4 | CAR | Ferguson et al., 2002a | |
CYP2C45 | Chicken | DR-4 | CXR | Baader et al., 2002 | |
CYP2H1 | Chicken | DR-4 | CXR | Handschin and Meyer, 2000 | |
CYP3A2 | Rat | DR-3 | PXR | Sueyoshi and Negishi, 2001 | |
CYP3A4 | Human | ER-6, DR-3, DR-4 | PXR, CAR | Sueyoshi and Negishi, 2001 | |
CYP3A7 | Human | ER-6 | PXR | Sueyoshi and Negishi, 2001 | |
CYP3a11 | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
CYP3A23 | Rat | DR-4 | PXR | Sueyoshi and Negishi, 2001 | |
CYP3A37 | Chicken | DR-4 | CXR | Podvinec et al., 2002 | |
Aldh1 | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
Est1 | Mouse | ? | CAR | Ueda et al., 2002a | |
F-monoox. | Mouse | ? | CAR | Ueda et al., 2002a | |
Drug conjugation (phase II) | GST | Mouse | ? | CAR | Maglich et al., 2002 |
Sultn | Mouse | ? | CAR | Maglich et al., 2002 | |
Std | Mouse | IR-0 | PXR | Sonoda et al., 2002 | |
UGT1A1 | Human | DR-4 | CAR | Sugatani et al., 2001 | |
Ugt1a1 | Mouse | ? | PXR | Maglich et al., 2002 | |
Drug import/export | MDR1 | Human | DR-4 | PXR | Geick et al., 2001 |
Mdr1a | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
Mdr1b | Mouse | ? | PXR | Maglich et al., 2002 | |
Mrp1 | Mouse | ? | CAR | Maglich et al., 2002 | |
Mrp2 | Mouse | ER-8 | PXR, CAR | Kast et al., 2002 | |
Mrp3 | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
Oatp2 | Mouse | ? | PXR | Maglich et al., 2002 | |
OATP2 | Rat | DR-3 | PXR | Guo et al., 2002 | |
Essential accessory proteins | ALAS1 | Chicken | DR-4 | CXR | Fraser et al., 2002 |
Alas1 | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
Methyltransferase | Mouse | ? | CAR | Ueda et al., 2002a | |
PAPS synthase | Mouse | ? | CAR, PXR | Ueda et al., 2002a | |
Por | Mouse | ? | PXR, CAR | Maglich et al., 2002 | |
Receptors | AhR | Mouse | ? | CAR | Maglich et al., 2002 |
CAR | Mouse | ? | PXR | Maglich et al., 2002 | |
ear-2 | Human | ? | CAR | Sugatani et al., 2001 | |
PXR | Mouse | ? | PXR | Maglich et al., 2002 | |
Other enzymes and proteins | Aquaporin 1 | Mouse | ? | CAR | Ueda et al., 2002a |
cAMP-reg. PP | Mouse | ? | CAR | Ueda et al., 2002a | |
IGFBP1 | Human | ? | CAR | Sugatani et al., 2001 | |
HD | Mouse | DR-2 | CAR | Kassam et al., 2000 | |
iNOS | Human | DR-4 | PXR, CAR | Toell et al., 2002 | |
Semaphorin-3 | Mouse | ? | CAR | Ueda et al., 2002a | |
SOD3 | Human | ? | CAR | Sugatani et al., 2001 |
↵ a List of target genes that are induced by any of the xenosensors. Genes included were identified as direct target genes with response elements or found to be reduced in PXR or CAR knockout animals. References are either reviews or primary papers describing the respective genes. See text for details or further references. Abbreviations: Aldh, aldehyde dehydrogenase; Est, esterase; GST, glutathione S-transferase; Sultn, sulfotransferase; Std, dehydroepiandrosterone sulfotransferase; UGT, UDP-glucuronosyl transferase; Mdr, intestinal P-glycoprotein; Mrp, multidrug-resistance protein; Oatp, organic anion transporting peptide; F-monoox, flavin containing mono-oxygenase; Por, cytochrome P450 oxidoreductase; iNOS, inducible nitric-oxide synthase; cAMP-reg. PP, cAMP-regulated phosphoprotein; SOD, superoxide dismutase; IGFBP, insulin-like growth factor-binding protein; HD, enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase