Malformation | Incidence | Percentage (n = 67-70) |
---|---|---|
Craniofacial abnormalities | Small/broad nose | 57 |
Small/abnormal ears | 46 | |
Long/flat philtrum | 43 | |
Thin vermillion border | 37 | |
Epicanthal folds | 31 | |
Hypertelorism | 27 | |
High/broad forehead | 26 | |
Micro/retrognathia | 26 | |
Bifrontal narrowing | 17 | |
Organ malformations | Musculoskeletal system | 63 |
Skin and appendages | 29 | |
Cardiac abnormalities | 26 | |
Genital abnormalities | 16 | |
Brain abnormalities | 10 | |
Evolution | Developmental deficits | 20 |
Growth retardation | 15 | |
Hypotonia | 10 | |
Mental retardation | 10 |
Adapted from Kozma (2001).