Prodrugs activated by carboxylesterase
| Prodrug | Drug | Pharmacology | Reference |
|---|---|---|---|
| CPT-11 | SN-38 | Topoisomerase I inhibitor | Satoh et al., 1994 |
| Paclitaxel-2-ethylcarbonate | Paclitaxel | Microtubule-binding agent | Senter et al., 1996 |
| Capecitabine | 5′-Deoxy-5-fluorocytidine (5-FU) | Thymidylate synthase inhibitor/incorporated into DNA and RNA | Miwa et al., 1998 |
| Tertiary amidomethyl esters | Carboxylic acids and aminesa | Not reported | Iley et al., 1999 |
↵ a These product were obtained after carboxylesterase-mediated cleavage of esters; however, pharmacology of the carboxylic acids and amines is not reported.