Prodrug | Drug | Pharmacology | Reference |
---|---|---|---|
Streptonigrin | Unidentified | DNA alkylation/oxidative stress | Kremer and Laszlo, 1966 |
Mitomycin C | Quinone methide intermediate | DNA alkylation/oxidative stress | Keyes et al., 1984 |
CB 1954 | 5-(Aziridin-1-yl)-4-hydroxyl-amino-2-nitrobenzamide | DNA alkylation/oxidative stress | Knox et al., 1988 |
Diaziquone | Semiquinone radicala | DNA alkylation/oxidative stress | Ross et al., 1990 |
↵ a DT-diaphorase activates diaziquone to its hydroquinone via a two-electron reduction, which auto-oxidates to a semiquinone radical (Fisher and Gutierrez, 1991).