Prodrugs activated by cytochrome P450
| Prodrug | Drug | Pharmacology | Reference |
|---|---|---|---|
| 4-Ipomeanol | Unidentified (furan epoxide is speculated) | DNA alkylation | Boyd, 1977 |
| Ftorafur (tegafur) | 5-FU | Thymidylate synthase inhibitor/incorporated into DNA and RNA | Kawata et al., 1984 |
| Dacarbazine | HHMTIC | DNA alkylation | Meer et al., 1986 |
| Trofosfamide | Trofosfamide mustard | DNA alkylation | Della Morte et al., 1986 |
| Ifosfamide | Isophosphamide mustard | DNA alkylation | Della Morte et al., 1986 |
| Cyclophosphamide | Phosphoramide mustard | DNA alkylation | Roy et al., 1999 |
| AQ4N | AQ4 | Topoisomerase II inhibitor | Raleigh et al., 1998 |