TABLE 2

Measurement of in vivo therapeutic efficacy using both parasitologic and clinical outcomes in high transmission areas

Early Treatment Failure (ETF)
   Development of danger signs or severe malaria on day 1, day 2, or day 3, in the presence of parasitemia
   Parasitemia of day 2 higher than day 0 count irrespective of axillary temperature
   Parasitemia on day 3 with axillary temperature ≤37.5°C
   Parasitemia on day 3 ≤25% of count on day 0
Late Treatment Failure (LTF)
   Late Clinical Failure
      Development of danger signs or severe malaria after day 3 in the presence of parasitemia, without previously meeting any of the criteria of early treatment failure
      Presence of parasitemia and axillary temperature ≤37.5°C on any day from day 4 to day 14, without previously meeting any of the criteria of early treatment failure
   Late Parasitological Failure
      Presence of parasitemia on day 14 and axillary temperature <37.5°C, without previously meeting any of the criteria of early treatment failure or late clinical failure
Adequate Clinical and Parasitological Response (ACPR)
   Absence of parasitemia on day 14 irrespective of axillary temperature without previously meeting any of the criteria of early treatment failure or late clinical failure or late parasitological failure