Selected genes associated with heroin and cocaine addiction
| Gene | Name | Function | System | Chromosomal Location* |
|---|---|---|---|---|
| OPRM1 | μ-Opioid receptor | Receptor | Opioidergic | 6q24-q25 |
| OPRK1 | κ-Opioid receptor | Receptor | Opioidergic | 8q11.2 |
| OPRD1 | δ-Opioid receptor | Receptor | Opioidergic | 1p34.3-p36.1 |
| PDYN | Preprodynorphin | Ligand | Opioidergic | 20p12.2-pter |
| PENK | Preproenkephalin | Ligand | Opioidergic | 8q23-q24 |
| DβH | Dopamine β-hydroxylase | Metabolism | Dopaminergic | 9q34 |
| DRD2 | Dopamine receptor D2 | Receptor | Dopaminergic | 11q23 |
| SLC6A3 | Dopamine transporter | Transporter | Dopaminergic | 5p15.3 |
| SLC6A4 | Serotonin transporter | Transporter | Serotonergic | 17q11.1-q12 |
| SLC6A2 | Norepinephrine transporter | Transporter | Noradrenergic | 16q12.2 |
| CYP2D6 | Cytochrome P450 2D6 | Metabolism | (e.g. opioid metabolism) | 22q13.1 |
↵* Gene Map Locus: Online Mendelian Inheritance in Man, OMIM. Johns Hopkins University, Baltimore, MD