Inhibitors of NOS-I (nNOS) | | | | | |
5-Ethyl-N-[4-trifluoro(methyl)phenyl]-isothiourea |
K
i
| 0.32 μM | 37 μM | 9.4 μM |
Wolff et al., 1994
|
α-Fuanidinoglutaric acid | | | | |
Shearer et al., 1997
|
l-N5-(1-Iminoethyl)-ornithine (l-NIO) |
K
i
| 1.7 μM | 3.9 μM | 3.9 μM |
Yokoi et al., 1994
|
N5-(1-Imino-3-butenyl)-l-ornitine |
K
i
| 0.1 μM | 60 μM | 12 μM |
Furfine et al., 1994
|
7-Nitroindazole | IC50 | 0.71 μM | | 0.80 μM |
Rees et al., 1990
|
3-Bromo-7-nitroindazole | IC50 | 170 nM | ≈200 nM | |
Babbedge et al., 1993
|
Nω[ρ]-Propyl-l-arginine |
K
i
| 0.057 μM | 180 μM | 8.5 μM |
Zhang et al., 1997
|
l-Thiocitrulline |
K
i
| 0.06 μM | 3.6 μM | |
Furfine et al., 1994
|
S-Methyl-l-thiocitrulline | IC50 | 0.3 μM | | 5.4 μM | Handy et al., 1936 |
1-(2-Trifluoromethylphenyl)imidazole | IC50 | 28.2 μM | 27.0 μM | 1.06 mM |
Babu and Griffith, 1998a
|
Inhibitors of NOS-II (iNOS) | | | | | |
S-Methyl-isothiourea |
K
i
| | 6 μM | | Webber et al., 1998 |
S-(2-Aminoethyl)-isothiourea |
K
i
| | 6 μM | |
Garvey et al., 1994
|
2-Imino-4-methylpiperidine | IC50 | 0.2 μM | 0.1 μM | 1.1 μM |
Griffiths et al., 1993
|
Aminoguanidine |
K
i
| 157 μM | 75 μM | |
Garvey et al., 1994
|
l-N5-(1-Iminoethyl)-ornithine (l-NIO) |
K
i
| 1.7 μM | 3.9 μM | 3.9 μM |
Rees et al., 1990
|
l-Thiocitrulline |
K
i
| 0.06 μM | 3.6 μM | |
Furfine et al., 1994
|
Inhibitors of NOS-III (eNOS) | | | | | |
S-Ethyl-isothiourea |
K
i
| 0.029 μM | 0.017 μM | 0.036 μM |
Nakane et al., 1995
|
S-Isopropyl-ITU |
K
i
| | 0.01 μM | |
Rees et al., 1990
|
l-N5-(1-Iminoethyl)-ornithine (l-NIO) |
K
i
| 1.7 μM | 3.9 μM | 3.9 μM |
Southan et al., 1995
|