TABLE 3

Class 3 G protein-coupled receptors Family represents the classification of orphan receptors adapted from Vassilatis et al. ( 2003 ). The IUPHAR Receptor Code is described in Humphrey and Barnard ( 1998 ). A representative, but not necessarily complete list of putative endogenous ligands is given. Provisional nomenclature is given in square brackets. NC-IUPHAR does not normally allocate names to receptors where there is only a single publication identifying the putative endogenous ligand. Gene symbol approved by the HUGO Gene Nomenclature Committee (http://www.gene.ucl.ac.uk/nomenclature/). Gene IDs from Entrez Gene (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene).

Family IUPHAR Receptor Code Ligand Official IUPHAR Nomenclature Human Gene Symbol Human Gene ID Mouse Gene ID Rat Gene ID
GABAB 2.3:GABA:1:GABAB1: GABAa GABAB1 GABBR1 2550 54393 81657
GABAB 2.3:GABA:2:GABAB2: None GABAB2 GPR51 9568 242425 83633
GABAB [GABABL] GPR156 165829 260430
Metabotropic glutamate 2.3:GLU:1:MGLU1: Glutamate mGlu1 GRM1 2911 14816 24414
Metabotropic glutamate 2.3:GLU:2:MGLU2: Glutamate mGlu2 GRM2 2912 108068 24415
Metabotropic glutamate 2.3:GLU:3:MGLU3: Glutamate mGlu3 GRM3 2913 108069 24416
Metabotropic glutamate 2.3:GLU:4:MGLU4: Glutamate mGlu4 GRM4 2914 108070 24417
Metabotropic glutamate 2.3:GLU:5:MGLU5: Glutamate mGlu5 GRM5 2915 108071 24418
Metabotropic glutamate 2.3:GLU:6:MGLU6: Glutamate mGlu6 GRM6 2916 108072 24419
Metabotropic glutamate 2.3:GLU:7:MGLU7: Glutamate mGlu7 GRM7 2917 108073 81672
Metabotropic glutamate 2.3:GLU:8:MGLU8: Glutamate mGlu8 GRM8 2918 14823 60590
Calcium sensor 2.3:CASN:1:CAS: Calcium CaS CASR 846 12374 24247
Calcium sensor GPRC6A 222545 210198
GPRC5 [RAIG1] GPRC5A 9052
GPRC5 [RAIG2] GPRC5B 51704 64297
GPRC5 [RAIG3] GPRC5C 55890 70355
GPRC5 GPRC5D 55507 93746
Unclassified GPR158 57512 241263 291352
Unclassified GPR158L1 342663 287657
  • a Functional GABA receptors contain both GABAB1 and GABAB2 subunits