KV7.5 channels
| Channel name | KV7.5 |
| Description | Voltage-gated potassium channel, delayed rectifier |
| Other names | None |
| Molecular information | Human: 932aa, NM_019842, chr. 6q14, KCNQ,1,5 GeneID: 56479, PMID: 107874161 |
| Mouse: 933aa, NM_023872, chr. 1 | |
| Rat: 953aa, XM_237012 (predicted), chr. 9 | |
| Associated subunits | KCNQ3 |
| Functional assays | Voltage-clamp |
| Current | M current1 |
| Conductance | Not established |
| Ion selectivity | K+ |
| Activation | Va = 30 mV |
| Inactivation | Not established |
| Activator | Retigabine (KCNQ5/KCNQ3: 1.4 μM),2 BMS204352 (2.4 μM)3 |
| Gating inhibitors | None |
| Blockers | Tetraethyammonium (>30 mM),1 linopiridine (16 μM),1 linopiridine KCNQ5/KCNQ3 (7.7 μM),2 XE9913 |
| Radioligands | None |
| Channel distribution | Brain, sympathetic ganglia (splice variant I),4 skeletal muscle (splice variant III)4 |
| Physiological functions | Determines subthreshold excitability of neurons |
| Mutations and pathophysiology | A number of allelic variants have been identified |
| Pharmacological significance | Anticonvulsants (activators) |
aa, amino acids; chr., chromosome; XE991, 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one; BMS204352, 3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2- one.
↵1. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, and Steinmeyer K (2000) Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem 275:22395-22400
↵2. Wickenden AD, Zou A, Wagoner PK, and Jegla T (2001) Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol 132:381-384
↵3. Dupuis DS, Schroder RL, Jespersen T, Christensen JK, Christophersen P, Jensen BS, and Olesen SP (2002) Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352. Eur J Pharmacol 437:129-137
↵4. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, and Jentsch TJ (2000) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem 275:24089-24095