KV1.7 channels
| Channel name | KV1.71,2,3 |
| Description | Voltage-gated potassium channel, delayed rectifier |
| Other names | None |
| Molecular information | Human: 456aa, NM_031886, chr. 19q13.31,2,3, KCNA7, GeneID: 3743, PMID: 113689076 |
| Mouse: 532aa, NM_010596, chr. 7 | |
| Rat: 457, XM_344889 (predicted), chr. 1q22 | |
| Associated subunits | None identified |
| Functional assays | Voltage-clamp |
| Current | Possibly a component of IKur in the heart3 |
| Conductance | 21pS1 |
| Ion Selectivity | K+ |
| Activation | Voltage, Va = –8 mV; τn = 6 ms (30 mV)3 |
| Inactivation | Very slow inactivation |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Flecainide (8 μM), quinidine (15 μM), verapamil (16 μM), amiodarone (35 μM), 4-aminopyridine (150 μM), tetraethyammonium (150 mM)3 |
| Radioligands | None |
| Channel distribution | Placenta, amnion, islets (mouse), skeletal muscle, heart, pulmonary arteries4,5 |
| Physiological functions | KV1.7 has properties similar to the ultrarapidly activating IKur current in the heart3 |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | Can coassemble with other KV1 family members in heteromultimers but not with members of other KV families; only member of this family that has an intron in the coding region1,2,3; mammalian Shaker-related family |
aa, amino acids; chr., chromosome.
↵1. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, et al (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem 273:5851-5857
↵2. Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlstedt C, Wasserman WW, Zabarovsky ER (2001) Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene 268:115-122
↵3. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, and Corfield V (2002) Characterization of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as a cause of progressive familial heart block I (PFHBI). Eur J Human Genet 10:36-43
↵4. UniGene Cluster Hs0.306973; OMIM no. 176268
↵5. Davies AR and Kozlowski RZ (2001) Kv channel subunit expression in rat pulmonary arteries. Lung 179:147-161
↵6. Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlestedt C, Wasserman WW, and Zabarovsky ER (2001) Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene 268:115-122