KV1.8 channels
| Channel name | KV1.8 |
| Description | Voltage-gated potassium channel, delayed rectifier |
| Other names | KV1.10, Kcn11,2,3,4,5 |
| Molecular information | Human: 511aa, NM_005549, chr. 1p13.1, KCNA10, GeneID: 3744, PMID: 91777731 |
| Mouse: 503aa, XM_143471 (predicted), chr. 3 | |
| Rat: 511aa, XM_227577 (predicted), chr. 2q34 | |
| Associated subunits | KCNA4B |
| Functional assays | Voltage-clamp |
| Current | Possibly a component of IKur in the heart2 |
| Conductance | 10–12pS2 |
| Ion selectivity | K+/Na+ > 70:12 |
| Activation | Va =3.6 mV (oocytes); τa =18 ms at +60 mV (oocytes)2 |
| Inactivation | τh = 10 s |
| Activators | CGMP |
| Gating inhibitors | None |
| Blockers | Barium (5 mM), tetraethyammonium (50 mM), 4-aminopyridine (1.5 mM), charybdotoxin (100 nM), ketoconazole (500 nM), pimozide (300 nM), verapamil (45 μM)2 |
| Radioligands | None |
| Channel distribution | Kidney (cortex > medulla), brain, heart, skeletal muscle, adrenal gland1,2,3,6 |
| Physiological functions | Regulation of membrane potential in renal proximal tubule |
| Mutations and pathophysiology | None |
| Pharmacological significance | Not established |
| Comments | Can coassemble with other KV1 family members in heteromultimers but not with members of other KV families; intronless coding region; mammalian Shaker-related family |
aa, amino acids; chr., chromosome.
↵1. Orias M, Bray-Ward P, Curran ME, Keating MT, and Desir GV (1997) Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics 42:33-37
↵2. Lang R, Lee G, Liu W, Tian S, Rafi H, OriasM, Segal AS, and Desir GV (2000) KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol 278:F1013-F1021
↵3. Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, and Desir GV (1995) Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA 92:11711-11715
↵4. Yao X, Liu Y, Tung F, and Desir GV (1996) Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. Am J Physiol 271:F37-F41
↵5. Iwasa H, Kurabayashi M, Nagai R, Nakamura Y, and Tanaka T (2001) Genetic variations in five genes involved in the excitement of cardiomyocytes. J Hum Genet 46:549-552
↵6. UniGene Cluster Hs0.306973; OMIM no. 176268