TABLE 1

Receptor sites on sodium channels

Receptor Site Toxin or Drug Domains
Neurotoxin receptor site 1 Tetrodotoxin IS2–S6, IIS2–S6
Saxitoxin IIIS2–S6, IVS2–S6
μ-Conotoxin
Neurotoxin receptor site 2 Veratridine IS6, IVS6
Batrachotoxin
Grayanotoxin
Neurotoxin receptor site 3 α-Scorpion toxins IS5–IS6, IVS3–S4
Sea anemone toxins IVS5–S6
Neurotoxin receptor site 4 β-Scorpion toxins IIS1–S2, IIS3–S4
Neurotoxin receptor site 5 Brevetoxins IS6, IVS5
Ciguatoxins
Neurotoxin receptor site 6 δ-Conotoxins IVS3–S4
Local anesthetic receptor site Local anesthetic drugs IS6, IIIS6, IVS6
Antiarrhythmic drugs
Antiepileptic drugs