K2P13.1 channels
| Channel name | K2P13.1 |
| Description | Two-pore domain potassium channel subunit; open rectifier1 |
| Other names | KCNK13, THIK-1 |
| Molecular information | Human: 408aa, NM_022054, chr0.14q24.1-24.3, KCNK13, GeneID: 56659, PMID: 110603161 |
| Rat: 405aa, NM_022293, kcnk13 | |
| Mouse: not cloned | |
| Associated subunits | Not established |
| Functional assays | Electrophysiological |
| Current | Open rectifier |
| Conductance | Not established |
| Ion selectivity | Not established |
| Activation | See “Comments” |
| Inactivation | See “Comments” |
| Activators | Arachidonic acid (0.98 mM) |
| Gating inhibitors | None |
| Blockers | Ba2+, halothane (2.83 mM) |
| Radioligands | None |
| Channel distribution | Brain, heart, lung, kidney, liver, spleen |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | Activation and deactivation with voltage steps seem to be instantaneous; K2P13-like channels are found in the central nervous system of Aplysia californica2 |
aa, amino acids; chr., chromosome.
↵1. Rajan S, Wischmeyer E, Karschin C, Preisig-Muller R, Grzeschik KH, Daut J, Karschin A, and Derst C (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem 276:7302-7311
↵2. Jezzini SH and Moroz LL (2004) Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica. Brain Res Mol Brain Res 27:7-38