K2P17.1 channels
| Channel name | K2P17.1 |
| Description | Two-pore domain potassium channel subunit; open rectifier |
| Other names | KCNK17, TASK-4, TALK-2 |
| Molecular information | Human: 332aa, NM_031460, chr0.6p21.1-2, KCNK17,1 GeneID: 89822, PMID: 112639991 |
| Rat: not cloned | |
| Mouse: not cloned | |
| Associated subunits | Not established |
| Functional assays | Electrophysiological1 |
| Current | Open rectifier |
| Conductance | Not established |
| Ion selectivity | Not established |
| Activation | See “Comments” |
| Inactivation | See “Comments” |
| Activators | Nitric oxide and reactive oxygen species3 |
| Gating inhibitors | None |
| Blockers | Ba2+, external pH,2,3 chloroform (∼800 mM) |
| Radioligands | None |
| Channel distribution | Heart, lung, liver, pancreas,1 placenta |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | Activation and deactivation with voltage steps seem to be instantaneous; the open probability of K2P17 increases as pHo is raised above physiological levels (see K2P16) |
aa, amino acids; chr., chromosome.
↵1. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, and Lesage F (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem Biophys Res Commun 282:249-256
↵2. Decher N, Maier M, Dittrich W, Gassenhuber J, Bruggemann A, Busch AE, and Steinmeyer K (2001) Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family. FEBS Lett 492:84-89
↵3. Duprat F, Girard C, Jarretou G, and Lazdunski M (2004) Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J Physiol 562:235-244