Channel name | TRPML11,2 |
Description | Nonselective cation channel subunit |
Other names | MCOLN1, mucolipin 1 |
Molecular information | Human unigene: Hs0.310431, chr. 5q31 |
Mouse unigene: Mm0.226899, chr. 18 C | |
Associated subunits | Not established |
Functional assays | Patch-clamp, calcium imaging |
Current | Not established |
Conductance | 300pS? |
Ion selectivity | PNa/PCa ∼1 |
Activation | Not established |
Inactivation | Not established |
Activators | [Ca2+]i? |
Gating inhibitors | Not established |
Blockers | Amiloride (130 μM), Gd3+, La3+, Ni2+ |
Radioligands | Not established |
Channel distribution | Widely expressed, heart kidney, testis, blood |
Physiological functions | Not established |
Mutations and pathophysiology | Not established |
Comments | Electrophysiological properties not firmly established |
chr., chromosome.
↵1. LaPlante JM, Falardeau J, Sun M, KanazirskaM, Brown EM, Slaugenhaupt SA, and Vassilev PM (2002) Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett 532:183-187
↵2. LaPlante JM, Ye CP, Quinn SJ, Goldin E, Brown EM, Slaugenhaupt SA, and Vassilev PM (2004) Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. Biochem Biophys Res Commun 322:1384-1391