CNG4A channels
| Channel name | CNGA41,2 |
| Description | Cyclic nucleotide-gated cation channel A subunit |
| Other names | CNG5, CNGa4, OCNC2, CNGB2 |
| Molecular information | Human: 575aa, XM_290552, XP_290552, chr. 11p15.4 |
| Rat: 575aa, NM_053496, NP_445948, chr. 1q32 | |
| Mouse: 575aa, XM_145875, XP_145875, chr. 7 E3 | |
| Associated subunits | CNGA2, CNGB1b |
| Functional assays | When assembled with CNGA2 and CNGB1b subunits: patch-clamp, calcium imaging |
| Current | Not functional on its own |
| Conductance | Not established |
| Ion selectivity | Not established |
| Activation | Not established |
| Inactivation | Not established |
| Activators | None |
| Gating modifiers | Ca2+-calmodulin (in native olfactory channel) |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Olfactory neurons, some central neurons |
| Physiological functions | Modulatory subunit of native olfactory CNG channel: increases cAMP sensitivity and accelerates Ca2+-calmodulin-dependent odor adaptation |
| Mutations and pathophysiology | Not established in humans |
| Pharmacological significance | Not established |
aa, amino acids; chr., chromosome.
↵1. Bradley J, Li J, Davidson N, Lester HA, and Zinn K (1994) Heteromeric factory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA 91:8890-8894
↵2. Liman ER and Buck LB (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13:611-621