Therapeutic Target | No. of U.S. Patents | Targeted Diseases | |
---|---|---|---|
Protein | Subgroup | ||
MMPs (79) | Matrix metalloproteinase | 62 | Arthritis, cancers, tissue ulceration, periodontal disease, bone disease, diabetes |
MMP-1 | 1 | Pulmonary emphysema | |
MMP-2 | 12 | Cancers | |
MMP-3 | 9 | Multiple sclerosis, heart failure, cancers, inflammation, arthritis, autoimmune disorders | |
MMP-4 | 1 | Arthritis, cancers | |
MMP-7 | 1 | Inflammatory diseases, rheumatoid arthritis, tumors | |
MMP-8 | 1 | Inflammatory diseases, cancers | |
MMP-9 | 5 | Cancers, arthritis | |
MMP-11 | 1 | Cancers | |
MMP-12 | 1 | Ulcerative colitis, Crohn's disease, atherosclerosis, gastrointestinal ulcers, emphysema | |
MMP-13 | 9 | Osteoarthritis, rheumatoid arthritis, cancers, inflammation, heart failure | |
PDEs (78) | Phosphodiesterase | 3 | Erectile dysfunction, sexual dysfunction |
PDE1A | 2 | Cardiovascular and cerebrovascular disorders, erectile dysfunction | |
PDE2A | 2 | Cardiovascular and cerebrovascular disorders, disorders of urogenital system | |
PDE3 | 5 | Airway obstructions, inflammatory diseases, premature ejaculation, sexual dysfunction | |
PDE4 | 49 | Airway obstructions, inflammatory diseases, allergic disorders | |
PDE4A | 1 | Respiratory disorders, asthma | |
PDE7 | 4 | Asthma, rheumatoid arthritis, psoriasis, atopic dermatitis, chronic bronchitis | |
αv Integrin receptors (40) | αva3 Integrin receptor | 39 | Cancers, arteriosclerosis, restenosis, osteolytic disorders, osteoporosis, ophthalmic diseases |
αva5 Integrin receptor | 16 | Cancers, osteoporosis, arteriosclerosis,r estenosis, ophthalmia | |
Farnesyl-protein transferase (26) | Cancers, restenosis, atherosclerosis | ||
Tumor necrosis factor-α-converting enzyme (25) | Arthritis, tumor metastasis, tissue ulceration, bone disease, diabetes, HIV infection | ||
Cathepsin K (23) | Autoimmune diseases, cartilage degradation, osteoporosis, pulmonary disorders | ||
Substance receptor (22) | Asthma, cough, bronchospasm, depression, inflammation, gastrointestinal disorders | ||
Tachykinin NK3 receptor (19) | CNS disorders, inflammation, pain, migraine, asthma, emesis, gastrointestinal disorders | ||
Neuropeptide Y receptor (18) | Neuropeptide Y receptor | 10 | Eating disorders, feeding disorders, cardiovascular disorders, physiological disorders |
Neuropeptide Y5 receptor | 8 | Eating disorders, diabetes, nutritional disorders, obesity | |
Cyclin-dependent kinases (17) | Cyclin-dependent kinase | 12 | Cancers, inflammation, arthritis, Alzheimer's disease, cardiovascular disorders |
Cell division protein kinase 2 | 4 | Alopecia, cancers | |
Cell division protein kinase 4 | 1 | Cancers | |
Stress kinase p38 (17) | Chronic inflammatory, autoimmune diseases, hypercholesterolemia | ||
Hexokinase D (17) | Type 2 diabetes | ||
Phospholipase A2 (16) | Phospholipase A2 | 12 | Inflammatory diseases, allergic diseases, pancreatitis, septic shock |
Cytosolic phospholipase A2 | 4 | Inflammation, asthma, arthritis, inflammatory bowel disease, neurodegenerative diseases | |
Cytochrome P450RAI (15) | Skin diseases, cancers, cardiovascular diseases, inflammation, neurodegenerative diseases | ||
Cathepsin S (14) | Osteoporosis, autoimmune disorders | ||
Vasopressin receptor (13) | Vasopressin receptor | 4 | Cerebrovascular disease, cerebral edema, cerebral infarction, depressant, anxiety |
Vasopressin V1a receptor | 4 | Obsessive-compulsive disorder, aggressive disorders, depression, anxiety | |
Vasopressin V2 receptor | 7 | Diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, coagulation disorders | |
Trypsin-like serine protease (13) | Thrombosis, ischemia, stroke, restenosis, inflammation | ||
Interleukin-8 receptor (13) | Inflammation | ||
Corticoliberin (12) | Circadian rhythm disorders, congestive heart failure, hypertension, metabolic disorders, stroke | ||
Cathepsin B (12) | Autoimmune diseases, pancreatitis, inflammatory airway disease, bone and joint disorders | ||
Cathepsin L (12) | Autoimmune diseases, myocardial infarction, inflammation, muscular dystrophies, Alzheimer's disease | ||
Caspases (12) | Caspase | 4 | Cancers |
Caspase-8 | 8 | Inflammation, cancers, autoimmune disorders, neuronal disorders | |
Caspase-9 | 1 | Inflammation, cancers, autoimmune diseases, ischemic diseases, neurodegenerative disorders | |
Chemokine receptors (12) | CCR1 | 2 | Inflammation, immune diseases |
CCR2 | 2 | Atherosclerosis, inflammatory diseases, immune disorders, transplant rejection, aids | |
CCR3 | 3 | Respiratory disorders, bronchus disorders, inflammatory diseases, allergy | |
CCR5 | 5 | Inflammatory diseases, viral infections (HIV) | |
Prenyl-protein transferase (12) | Cancers | ||
Prostaglandin E receptor (11) | Prostaglandin E receptor | 3 | Dry eye, keratoconjunctivitis, Sjögren's syndrome, ocular surface diseases, glaucoma |
Prostanoid EP2 receptor | 4 | Ocular hypotensive, glaucoma, mesangial proliferative glomerulonephritis | |
Prostanoid EP4 receptor | 4 | Renal failure, dry eye | |
PTP-1B (10) | Diabetes, obesity, autoimmune diseases, acute and chronic inflammation, osteoporosis, cancers | ||
Serine/threonine protein kinase (10) | Serine/threonine protein kinase | 2 | Tumor growth, restenosis, atherosclerosis, cancers |
Serine/threonine protein kinase 12 | 8 | Cancers, diabetes, Alzheimer's disease | |
Endothelin (9) | Endothelin | 7 | Angina, pulmonary hypertension, Raynaud's disease, migraine, heart failure, pain, respiratory disorders |
Endothelin-1 | 2 | Pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure | |
β-Lactamase (9) | Bacterial antibiotic resistance, bacterial infections | ||
Metabotropic glutamate receptor (9) | mGLUR | 7 | Neurological disorders, psychosis, schizophrenia, Alzheimer's disease, cognitive and memory disorders |
mGLUR1 | 1 | Neurological diseases, neurodegenerative diseases, psychotic diseases | |
mGLUR5 | 1 | Neurological disorders, psychiatric disorders | |
Interleukin-1β convertase (8) | Inflammatory and autoimmune diseases, bone disorders, proliferative disorders, infectious diseases | ||
Glutamate receptors (8) | Glutamate receptor, ionotropic kainate 1 | 3 | Headaches, neuronal disorders |
Glutamate receptor AMPA | 5 | Epilepsy, diseases resulting in muscle spasm, various neurodegenerative diseases, stroke | |
Aldose reductase (8) | Diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy | ||
Protease activated receptor 1 (8) | Aggregation of blood platelets, thrombosis, thromboembolism, myocardial infarction |
PTP-1B, protein tyrosine phosphatase 1B