Statistics for the number of similarity human similarity proteins of successful targets that are outside the protein family of the respective target A total of 190 successful targets with identifiable drug-binding domain are included in the analysis.
| No. of Similarity Proteins | No. of Targets with This No. of Similarity Proteins | Targets with This No. of Similarity Proteins | Examples of Targets |
|---|---|---|---|
| % | |||
| 0–5 | 97 | 51 | 5-Hydroxytryptamine 3 receptor, acetylcholinesterase, adenosine A2b receptor, ATP-sensitive K+ channel |
| 6–10 | 36 | 19 | α-1D adrenergic receptor, dopamine D1 receptor, histamine H1 receptor, HIV-1 reverse transcriptase, muscarinic acetylcholine receptor M1 |
| 11–20 | 15 | 10 | Coagulation factor VIIIa, epidermal growth factor receptor, HIV-1 protease, insulin receptor, κ-type opioid receptor |
| 21–40 | 26 | 11 | Androgen receptor, estrogen receptor, γ-aminobutyric acid B receptor, peroxisome proliferator activated receptor α |
| 41–80 | 9 | 5 | Lutropin-choriogonadotropic hormone receptor, sulfonylurea receptor 2B, thrombin, urokinase-type plasminogen activator |
| >80 | 7 | 4 | Human keratin, receptor-type protein-tyrosine phosphatase S, thyroid peroxidase, Toll-like receptor 7 |