Endogenous and xenobiotic substrates
Transporter | Substrates |
|---|---|
| P-gp | Daunorubicin, doxorubicin, vinblastine, vincristine, irinotecan, topotecan, etoposide, colchicine, paclitaxel, ritonavir, indinavir, digoxin, fexofenadine, cortisol, morphine, loperamide, ivermectin |
| MDR3 | Phosphatidylcholine, digoxin, vinblastine, paclitaxel, aureobasidin A |
| BSEP | Bile salts |
| MRP1 | Glutathione-, glucuronate-, and sulfate-conjugated organic anions; estradiol 17-β-d-glucuronide (E217βG), leukotriene C4 (LTC4), S-(2,4-dinitrophenyl) glutathione (DNP-SG) |
| MRP2 | Glutathione-, glucuronate-, and sulfate-conjugated organic anions; E217βG, LTC4, bilirubin glucuronide, DNP-SG, pravastatin, SN-38 glucuronide, irinotecan |
| MRP3 | Epipodophyllotoxins, methotrexate, vincristine, etoposide, E217βG, LTC4, glycocholate, glycochenodeoxycholate, taurodeoxycholate, taurochenodeoxycholate, glucuronides |
| MRP4 | Steroid and bile acid conjugates, nucleoside analogs, 6-mercaptopurine (6-MP), 9-(2-phosphonylmethoxyethyl)adenine (PMEA), cAMP, cGMP |
| MRP5 | 6-MP, PMEA, low affinity for cyclic nucleotides |
| MXR | Anthracyclines, mitoxantrone, bisantrene, topotecan, SN-38 |