Endogenous and xenobiotic substrates
Transporter | Substrates |
|---|---|
| OCT1 | MPP+, 5-hydroxytryptamine, buformin, choline, cimetidine, clonidine, debrisoquine, dopamine, epinephrine, norepinephrine, metformin, phenformin, pindolol, procainamide, ranitidine, serotonin, TEA, tyramine |
| OCT2 | Cimetidine, creatinine, dopamine, epinephrine, guanidine, histamine, norepinephrine, memantine, metformin, MPP+, phenformin, pindolol, procainamide, ranitidine, serotonin, TEA |
| OCT3 | Dopamine, epinephrine, histamine, MPP+, norepinephrine |
| OCTN1 | l-Ergothioneine, l-carnitine, TEA, betaine, quinidine, pyrilamine, verapamil |
| OCTN2 | l-Carnitine, l-lysine, l-methionine, cephaloridine, TEA, pyrilamine, verapamil, choline, quinidine |
| OAT1 | p-Aminohippurate, acetylsalicylate, acyclovir, adefovir, cidofovir, didanosine, ochratoxin A, tetracycline, zidovudine |
| OAT3 | Estrone sulfate, p-aminohippurate, urate, methotrexate, cAMP, cimetidine, ochratoxin A, salicylate, tetracycline |
MPP+, 1-methy-4-phenypyridinium; TEA, tetraethylammonium.