TABLE 4

Distribution of receptors for relaxin and relaxin-related peptides

Tissue/Species	RXFP1					RXFP2			RXFP3 Human	RXFP4 Human
Tissue/Species		Rat	Mouse	Human	Rat	Mouse	Human		RXFP3 Human	RXFP4 Human
Ovary	mRNA^a	Protein^w	mRNA^b	mRNA^q				mRNA^ab
Oviduct	mRNA^a	mRNA^c
Uterus	mRNA^a; protein^b^,^t^,^u	mRNA^c^,ⁿ^,^ad	mRNA^b^,^h^,^j; protein^h^,^y			mRNA^b^,^j		mRNA^ab
Cervix, vagina	Protein^b^,^t^,^v	mRNA^c^,^ad	Protein^y
Placenta		mRNA^ad	mRNA^b					mRNA^s^,^ab
Nipple	Protein^v	mRNA^c^,^ad	Protein^y
Breast	Protein^v	Protein^d	Protein^y
Testis	mRNA^a^,^f	mRNA^c^,^o^,^ad	mRNA^b	mRNA^l^,^q	mRNA^k	mRNA^b	mRNA^r	mRNA^s^,^ab
Prostate		mRNA^o	mRNA^b					mRNA^s^,^ab
Gubernaculum				mRNA^f^,^l	mRNA^k
Brain	mRNA^a^,^e^,^f^,ⁱ; protein^u	mRNA^c^,^ad	mRNA^b	mRNA^ae	mRNA^k	mRNA^b	mRNA^r^,^ac	mRNA^s^,^ab
Pituitary		mRNA^c					mRNA^ac
Kidney	mRNA^a		mRNA^b	mRNA^af		mRNA^b		mRNA^s
Heart	mRNA^a^,^e^,ⁱ; protein^u^,^x	mRNA^c^,^ad	mRNA^b					mRNA^ab
Lung		mRNA^g^,^ad	mRNA^b
Liver			mRNA^b
Intestine	mRNA^a	mRNA^ad						mRNA^ab
Colon	mRNA^a							mRN^s^,^ab
Adrenal	mRNA^a		mRNA^b				mRNA^r^,^ac	mRNA^ab
Thyroid			mRNA^b			mRNA^b^,^p		mRNA^s^,^ab
Thymus							mRNA^r	mRNA^s^,^ab
Salivary glands			mRNA^b					mRNA^s^,^ab
Muscle			mRNA^b			mRNA^b		mRNA^ab
Peripheral blood cells			mRNA^b			mRNA^b		mRNA^ab
Monocyte cell line THP-1			mRNA^m; protein^z			mRNA^m
Bone marrow			mRNA^b			mRNA^b		mRNA^ab
Skin		mRNA^a^,^d	mRNA^b

↵ a mRNA by Northern blot analysis (Hsu et al., 2000)
↵ b mRNA by RT-PCR, protein by immunohistochemical analysis (Hsu et al., 2002)
↵ c mRNA by lacZ reporter expression (Krajnc-Franken et al., 2004)
↵ d protein by immunohistochemical analysis (Ivell et al., 2003)
↵ e mRNA by RT-PCR (Kompa et al., 2002)
↵ f mRNA by RT-PCR (Kubota et al., 2002)
↵ g mRNA by RT-PCR (Samuel et al., 2003b)
↵ h mRNA by RT-PCR, protein by immunohistochemical analysis (Luna et al., 2004)
↵ i mRNA by RT-PCR (Samuel et al., 2004a)
↵ j mRNA by RT-PCR (Mazella et al., 2004)
↵ k mRNA by RT-PCR (Overbeek et al., 2001)
↵ l mRNA by Northern blot analysis (Kumagai et al., 2002)
↵ m mRNA by RT-PCR (Nguyen et al., 2003)
↵ n mRNA by RT-PCR (Siebel et al., 2003)
↵ o mRNA by RT-PCR (Samuel et al., 2003b)
↵ p mRNA by RT-PCR (Hombach-Klonisch et al., 2003)
↵ q mRNA by Northern blot analysis and in situ hybridization (Kawamura et al., 2004)
↵ r mRNA by RT-PCR (Liu et al., 2003b)
↵ s mRNA by RT-PCR (Liu et al., 2003a)
↵ t protein by receptor autoradiography (Osheroff et al., 1990)
↵ u protein by receptor autoradiography (Tan et al., 1999)
↵ v protein by immunohistochemistry (Kuenzi and Sherwood, 1995)
↵ w protein by receptor autoradiography (Yang et al., 1992)
↵ x protein by receptor autoradiography (Osheroff et al., 1992)
↵ y protein by immunohistochemistry (Kohsaka et al., 1998)
↵ z protein receptor binding (Parsell et al., 1996)
↵ ab mRNA by multitissue expression array or Northern blot analysis (Boels and Schaller, 2003)
↵ ac mRNA by RT-PCR (Matsumoto et al., 2000)
↵ ad mRNA by RT-PCR or Northern blot analysis (Scott et al., 2004)
↵ ae mRNA by in situ hybridization (Shen et al., 2005)
↵ af mRNA by RT-PCR and in situ hybridization (Fu et al., 2005)