Comparison among human, mouse, and rat orthologs of ALX The murine homologs Fpr-rs3 to Fpr-rs7 lack human counterparts, and their expression and function are not currently known. Arrows indicate either ↑ increased or ↓ decreased activity.
| Species | Human | Mouse | Rat | ||||
|---|---|---|---|---|---|---|---|
| Receptor | ALX | Lxa4r/fprl1 | Fpr-rs1 | Fpr-rs2/8C10 | ALX | ||
| Cell type | PMN | Monocyte | Recombinant systems | Recombinant systems | Recombinant systems | ||
| Specific binding | LXA4 | LXA4 | LXA4 | N.D. | FMLP (low affinity) | LXA4 | |
| LXA4-signaling | ↑ AA release ↑ PLD | ↑ [Ca2+] | ↓ NF-κB | ↑ GTPase ↑ IP3 | N.D. | ↑ IP3 | ↓ NF-κB |
| Bioaction | Anti-inflammation and proresolution |
N.D., not determined