Lipid and peptide ligands for FPR, ALX/FPRL1, and FPRL2
| Ligand | FPR | FPRL1 | FPRL2 | |||
|---|---|---|---|---|---|---|
| Kd | EC50 | Kd | EC50 | Kd | EC50 | |
| Lipid-derived agonists | ||||||
| LXA4 and ATL | 5 μM | 1.7 nM | ||||
| Bacteria-derived peptides | ||||||
| fMLF | 1 nM | >1 μM | >1 μM | |||
| Hp(2—20) | 300 nM | |||||
| Host-derived peptides | ||||||
| uPAR fragment | 83 nM | |||||
| Annexin 1 | 900 nM | |||||
| MHC binding peptide | 1 nM | |||||
| SAA | 45 nM | |||||
| LL-37 | 5 μM | |||||
| CKβ8-1 | >1 μM | 1 nM | 1 μM | |||
| F2L | >1 μM | >1 μM | 10 nM | |||
| HIV-1 envelope peptides | ||||||
| T20/DP176 | ||||||
| T21/DP107 | 500 nM | |||||
| N36 | 10 μM | |||||
| F peptide | 10 μM | |||||
| V3 peptide | 1.5 μM | |||||
| Synthetic peptides | ||||||
| MMK-1 | 10 μM | 2 nM | ||||
| WKYMVm | 1 nM | 75 pM | 3 nM | |||
| Neuropeptides | ||||||
| PrP106—126 | 10 μM | |||||
| Aβ42 | 1.5 μM | |||||
| Humanin | 3.5 nM | |||||