Major points that justify the nomenclature for ALX in preference to FPRL1
| ALX | FPRL1 |
|---|---|
| Direct [3H]LXA4 binding and LXA4-dependent signaling events | Based on only DNA sequence homology; this receptor does not effectively bind and respond to fMLF |
| The ligand LXA4 is generated in vivo | Most of the peptide ligands are either protein fragments or surrogate or synthetic peptides; their presence in vivo is surmised |
| LXA4 evokes specific bioactions in vitro and in vivo in the low-to-subnanomolar range | Most of the peptide ligands evoke signals in vitro in the micromolar range |
| SAR–highly stereoselective in that the essential functional groups of LXA4 and ATL for receptor activation are also pharmacophores for their in vivo anti-inflammatory actions | No sequence similarities between peptide ligands; the structure requirement for receptor interaction is not available |