Whole blood | Down-regulate CD11b/CD18, prevent shedding of L-selectin and reduce peroxynitrite generation on PMNs, monocytes, and lymphocytes (Filep et al., 1999; Jozsef et al., 2002) |
Neutrophils | Inhibit chemotaxis, adherence and transmigration (Serhan et al., 1995) |
| Inhibit PMN-epithelial and PMN-endothelial cell interactions (Papayianni et al., 1996) |
| Block superoxide anion generation (Levy et al., 1999) |
| Reduce CD11b/CD18 expression and inositol triphosphate formation (Fiore and Serhan, 1995) |
| Inhibit peroxynitrite generation (Jozsef et al., 2002) |
| Attenuate AP-1 and NF-κB accumulation and inhibit IL-8 gene expression (Jozsef et al., 2002) |
Monocytes | Stimulate chemotaxis and adhesion to laminin without increase in cytotoxicity (Maddox and Serhan, 1996; Maddox et al., 1997) |
| Inhibit peroxynitrite generation (Jozsef et al., 2002) |
| Inhibit IL-8 release by cells obtained from asthma patients (Bonnans et al., 2002) |
Macrophages | Stimulate nonphlogistic phagocytosis of apoptotic PMNs (Godson et al., 2000; Mitchell et al., 2002) |
Dendritic cells | Block IL-12 production (Aliberti et al., 2002a) |
Eosinophils | Stop migration/chemotaxis in vivo and inhibit eotaxin and IL-5 generation (Lee et al., 1989; Bandeira-Melo et al., 2000a,b) |
Activated T cells | Inhibit TNF-α secretion by blocking ERK activation (Ariel et al., 2003) |
NK cells | Block cytotoxicity (Ramstedt et al., 1987) |
Myeloid progenitors | Stimulate myeloid bone marrow-derived progenitors (Stenke et al., 1991) |
Enterocytes | Inhibit TNF-α-induced IL-8 expression and release (Gewirtz et al., 2002) |
| Inhibit S. typhimurium-induced IL-8 (Gewirtz et al., 1998) |
Fibroblasts | Inhibit IL-1β-induced IL-6, IL-8, and MMP-3 production (Sodin-Semrl et al., 2000) |
Endothelia (HUVECs) | Stimulate protein kinase C-dependent prostacyclin formation (Brezinski et al., 1989) |
| Block P-selectin expression (Scalia et al., 1997) |
Mesangial cells | Inhibit LTD4-induced proliferation (McMahon et al., 2000) |
Pulmonary artery | Induce relaxation and reverse precontraction by PGF2α or endothelin-1 (Dahlén and Serhan, 1991) |
Hepatocytes | Reduce peroxisome proliferator-activated receptor-α and CINC-1 expression levels (Planagumà et al., 2002) |
Bronchi | Relaxation after precontraction by blocking peptido-leukotrienes in human airway (Christie et al., 1992) |