TABLE 1

Properties of various isoforms of brain PLA2 Data summarized from Hirashima et al. (1992); Matsuzawa et al. (1996); Yang et al. (1999); and Farooqui et al. (2000b).

Property sPLA2 cPLA2-α cPLA2-β cPLA2-γ PlsEtn-PLA2 iPLA2
Localization Extracellular Cytosol Cytosol Cytosol Cytosol Cytosol
Molecular mass (kDa) 14–18 85 114 61 39 80
Effect of calcium Stimulated (mM) Translocation Translocation Translocation No effect No effect
Preferred substrate PtdCho PtdCho PtdCho PtdCho PlsEtn PtdCho
Fatty acid specificity None AA AA AA AA, DHA Lino
Human chromosome 1 15 19 7
CalB domain Absent Present Present Absent Not known Absent
Effect of AACOCF3 No effect Inhibited Inhibited Inhibited Inhibited Inhibited
Effect of BEL No effect Inhibited Inhibited Inhibited Inhibited Inhibited

  • AA, arachidonic acid; Lino, linoleic acid