Property | sPLA2 | cPLA2-α | cPLA2-β | cPLA2-γ | PlsEtn-PLA2 | iPLA2 |
---|---|---|---|---|---|---|
Localization | Extracellular | Cytosol | Cytosol | Cytosol | Cytosol | Cytosol |
Molecular mass (kDa) | 14–18 | 85 | 114 | 61 | 39 | 80 |
Effect of calcium | Stimulated (mM) | Translocation | Translocation | Translocation | No effect | No effect |
Preferred substrate | PtdCho | PtdCho | PtdCho | PtdCho | PlsEtn | PtdCho |
Fatty acid specificity | None | AA | AA | AA | AA, DHA | Lino |
Human chromosome | 1 | 15 | 19 | 7 | ||
CalB domain | Absent | Present | Present | Absent | Not known | Absent |
Effect of AACOCF3 | No effect | Inhibited | Inhibited | Inhibited | Inhibited | Inhibited |
Effect of BEL | No effect | Inhibited | Inhibited | Inhibited | Inhibited | Inhibited |
AA, arachidonic acid; Lino, linoleic acid