Neuronal proteins targeted by the UPS
| Protein | Characterized Neuronal Function | Targeting Enzyme | References |
|---|---|---|---|
| PKA regulatory subunit | Enhanced degradation during Aplysia long-term facilitation | Hedge et al. (1993) | |
| LIM kinase 1 | Negative regulator of actin dynamics and axon outgrowth | Rnf6 | Tursun et al. (2005) |
| DLK/Wallenda | p38 pathway mitogen-activated protein kinase kinase kinase; misregulation disrupts synapse development in C. elegans | RPM-1 | Nakata et al. (2005); Collins et al. (2006) |
| Anaplastic lymphoma kinase | Receptor tyrosine kinase involved in neuronal differentiation and neurite outgrowth; misregulation prevents proper synapse development | RPM-1/FSN-1 complex | Liao et al. (2004) |
| UNC-13 | Presynaptic vesicle priming protein | Unknown | Speese et al. (2003) |
| Epsin 1 | Endocytic protein associated with the presynaptic compartment | Deubiquitinated by fat facets/FAM | Chen et al. (2003) |
| Shank | Multivalent PSD scaffolding protein | Unknown | Ehlers (2003a) |
| GKAP | Multivalent PSD scaffolding protein | Unknown | Ehlers (2003a) |
| AKAP79/150 | Multivalent PSD scaffolding protein | Unknown | Ehlers (2003a) |
| PSD-95 | Multivalent PSD scaffolding protein | Mdm2 | Colledge et al. (2003) |
| Liprin-α | Synapse development; presynaptic active zone function; AMPA receptor clustering | APC | Kaufmann et al. (2002); Zhen and Jin (1999); Wyszynski et al. (2002); van Roessel et al. (2004) |
| SPAR | PSD-associated actin-binding protein | Phosphorylation by Plk-2 causes degradation by unknown E3 ligase | Pak et al. (2001); Pak and Sheng (2003) |
| KEL-8 | BTB-Kelch protein involved in glutamate receptor clustering in C. elegans | Cullin3-containing SCF complexes | Schaefer and Rongo (2006) |
| β-Catenin/BAR-1 | Wnt pathway signalling molecule | SCFβ-TrCP | Dreier et al. (2005) |
| GLR-1 | C. elegans glutamate receptor | Unknown | Burbea et al. (2002) |
| NR1 | NMDA receptor subunit | SCFFbx2 | Kato et al. (2005) |