Ratio of therapeutic dose versus lethal dose against L1210 leukemia in mice: for calculation of therapeutic index or safety margin
| Therapeutic Effect | Lethal Toxicity | |||
|---|---|---|---|---|
| Dose of Therapy(D) | Fractional Leukemic Cell Survival (fu)a | Fractional Leukemic Cell Kill (fa = 1 – fu) | Dose of Treatment (D) | Fractional Lethality to the Host (fa) |
| mg/kg | ||||
| 0 mg/kg | 1 | 0 | 36.4 | 0.1 |
| 4.0 mg/kg | 10–1.05 | 0.9109 | 40 | 0.2 |
| 5.3 mg/kg | 10–2.37 | 0.99573 | 44 | 0.5 |
| 7.1 mg/kg | 10–3.24 | 0.9994246 | 53 | 0.7 |
| 9.5 mg/kg | 10–4.30 | 0.99994988 | 59 | 0.8 |
| 12.6 mg/kg | 10–5.61 | 0.999997545 | ||
| 16.9 mg/kg | 10–7.37 | 0.9999999573 | ||
↵ a Calculated from calibration curve for increasing size of leukemic cell inoculation and lifespan shortening as proposed by Skipper (1974)