Original Dataa | CompuSyn-Generated Resultsb | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Compound or Mixture | Concentration | % Killc | Dose-Effect Parameters | Combination Index at: | Dose-Reduction Index at: | ||||||||
m | Dm | r | ED50 | ED75 | ED90 | ED95 | ED50 | ED75 | ED90 | ED95 | |||
μg/ml | |||||||||||||
Rotenone (R) | 0.1 | 26.0 | |||||||||||
0.15 | 47.5 | ||||||||||||
0.20 | 67.5 | 2.626 | 0.151 | 0.907 | |||||||||
0.25 | 81.5 | ||||||||||||
0.35 | 89.5 | ||||||||||||
Pyrethrins (P) | 0.5 | 21.5 | |||||||||||
0.75 | 39.5 | ||||||||||||
1.0 | 54.0 | 2.387 | 0.893 | 0.995 | |||||||||
1.5 | 75.0 | ||||||||||||
2.0 | 89.0 | ||||||||||||
Rotenone + pyrethrins (1R:5P) | 0.3 | 27.0 | 2.01 | 1.97 | 1.94 | 1.92 | |||||||
0.45 | 53.0 | ||||||||||||
0.60 | 64.0 | 2.519 | 0.450 | 0.994 | 2.38 | 2.44 | 2.50 | 2.54 | |||||
0.875 | 82.0 | (0.075 + 0.375) | |||||||||||
1.175 | 93.0 | 0.9176 | 0.9163 | 0.9155 | 0.9152 | ||||||||
Rotenone + pyrethrins (1R:15P) | 0.4 | 23.0 | 3.70 | 3.64 | 3.59 | 3.55 | |||||||
0.6 | 48.0 | ||||||||||||
0.8 | 61.0 | 2.533 | 0.652 | 0.983 | 1.46 | 1.50 | 1.54 | 1.57 | |||||
1.2 | 76.0 | (0.041 + 0.611) | |||||||||||
1.6 | 93.0 | 0.9543 | 0.9465 | 0.9274 | 0.9187 |
↵ a Original data from Le Pelley and Sullivan (1936), retrieved and analyzed by Finney (1952), and analyzed by Chou and Talalay (1987)
↵ b Further analyzed by CompuSyn (Chou and Martin, 2005). The full computer printouts are given in Supplemental Data Appendix III (http://pharmrev.aspetjournals.org/cgi/content/full/pr.58.3.10/DC1)
↵ c Data for rotenone or pyrethrins alone were the average of two series of experiments