Trial Acronym | LDL/HDL | n | Years | Control (C) | Treatment (T) | %Δ LDL-C (T) | %Δ HDL-C (T) | IVUS Endpoint | Δ IVUS C/T (p) | Events C/T |
---|---|---|---|---|---|---|---|---|---|---|
mg/dl | ||||||||||
ASTEROID | 130/43 | 507 | 2 | Baseline | Rosuvastatin (40 mg) | –53 | +15 | Δ PAV | Baseline/–6.8 | N.A. |
REVERSAL | 150/42 | 502 | 1.5 | Pravastatin (40 mg) | Atorvastatin (80 mg) | –46 | +2.9 | %Δ TAV | +2.7/–0.4 (p = 0.02) | 9/6 |
GAIN | 161/46 | 131 | 1 | Usual care | Atorvastatin to target | –42 | +9 | %Δ PAV | +11.8/+2.5 (p = 0.138) | 2/2 |
ESTABLISH | 124/∼45 | 70 | 0.5 | Usual care | Atorvastatin (20 mg) | –42 | ∼+2.4 | %Δ TAV | +8.7/–13.1 (p < 0.0001) | 0/0 |
PTCA-Pravastatin | 170/35 | 25 | 3 | Diet | Pravastatin (10 mg) | –26 | +29 | %Δ PI | +27/–7 (p < 0.0005) | N.A. |
A-Plusa | <95/≤45 | 432 | <2 | Usual care | Avasimibe (50 mg) | +7.8 | +0.8 | Δ PAV | +0.4/+0.7 (N.S.) | 7/4 |
Avasimibe (250 mg | +9.1 | +1.2 | +0.4/+0.8 (N.S.) | 7/9 | ||||||
Avasimibe (750 mg) | +10.9 | +2.3 | +0.4/+1.0 (N.S.) | 7/2 | ||||||
ACTIVATEa | N.A. | 408 | 1.5 | Usual care | Pactimibe (100 mg) | –4.9 | –1.8 | Δ PAV | +0.59/+0.69 (N.S.) | 11/7 |
Apo A-IMilanoa | N.A. | 47 | 0.1 | Usual care | Apo A-IMilano (15 and 45 mg/kg) | N.A. | N.A. | Δ PAV | +0.14/–1.06 | N.A. |
PAV, percent atheroma volume; TAV, total atheroma volume; PI, plaque index; N.A., not applicable; N.S., not significant; PTCA, percutaneous transluminal coronary angioplasty; Apo A, apolipoprotein A; ASTEROID, A Study to Evaluate the Effect on Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden; GAIN, German Atorvastatin Intravascular Investigators; ESTABLISH, Early Statin Treatment in Patients with Acute Coronary Syndrome: Demonstration of Beneficial Effect on Atherosclerotic Lesions by Serial Volumetric IVUS Analysis during Half a Year after Coronary Event; ACTIVATE, Acyl-coenzyme A:cholesterol acyltransferase Intravascular Atherosclerosis Treatment Evaluation; A-Plus, Avasimibe and Progression of Lesions on Ultrasound
↵ a Nonstatin studies