Criteria | QCA | cIMT | IVUS | CRP |
---|---|---|---|---|
B1: Efficiency | ||||
Easy to measure | ? | √ | √ | √ |
Precedes the standard | √ | √ | √ | √ |
Quicker, easier (noninvasive) | — | √ | — | √ |
B2: Linkage | ||||
Quantitative and qualitative relationship based on epidemiologic and clinical trials | √ | √ | √ | ? |
Relationship understood via pathophysiology | √ | √ | √ | ? |
B3: Congruency | ||||
Parallel estimates of risk | √ | √ | √ | ? |
Different with/without disease | √ | √ | √ | √ |
Intervention trials show clinical benefit from Δ surrogate | √ | √ | ? | ? |
√, yes; –, no; ?, questionable