ALDH Isozyme | Reported Isozyme Description | Sourcea | Subcellular Location of Activityb | Km for DOPAL | References |
---|---|---|---|---|---|
ALDH1A1 | ALDH-E1 | H liver | Cytosol | 0.4 μM | MacKerell et al. (1986); Ambroziak and Pietruszko (1991) |
ALDH2 | ALDH2 | H recombinantc | Mitochondria | N.D. | Florang et al. (2006) |
ALDH2 | ALDH-E2 | H Liver | Mitochondria | 1.0 μM | MacKerell et al. (1986); Ambroziak and Pietruszko (1991) |
ALDH2 | Low Km MT ALDH | H brain | Mitochondria (MX) | 4.2 μM | Maring et al. (1985) |
ALDH3A1 | ALDH3A1 | H recombinantc | Cytosol | 15 μM | S. Marchitti and V. Vasiliou, unpublished data |
ALDH9A1 | ALDH-E3 | H liver | Cytosol | 2.6 μM | Ambroziak and Pietruszko (1991) |
ALDH1A1 | ALDH-II | H liver | Cytosol | 17 μM | Harada et al. (1982) |
Unknown | Similar to liver ALDH-E1 | H brain | Cytosol | 3 μM | Ryzlak and Pietruszko (1987) |
Unknown | Low Km cytosolic ALDH | H brain | Cytosol | 1.5 μM | Maring et al. (1985) |
Unknown | Cytosolic ALDHs (5 isozymes) | R liver | Cytosol | Range: 5 μM-3 mM | Tank et al. (1981) |
Unknown | Similar to liver ALDH-E2 | H brain | Mitochondria | <1 μM | Ryzlak and Pietruszko (1987) |
Unknown | Similar to liver ALDH-E2 | H Brain | Mitochondria | 0.5 μM | Ryzlak and Pietruszko, (1987) |
Unknown | Low Km MT ALDH | R Brain | Mitochondria (MX) | 0.3 μM | Pettersson and Tottmar (1982) |
Unknown | High Km MT ALDH | R Brain | Mitochondria (MX) | 31 μM | Pettersson and Tottmar (1982) |
Unknown | High Km MT ALDH | H Brain | Mitochondria (MB) | 197 μM | Maring et al. (1985) |
Unknown | MT ALDH | B Brain MT | Mitochondria | 10 μM | Erwin and Deitrich (1966) |
Unknown | MT ALDHs (3 isozymes) | R Liver | Mitochondria | Range: <1-180 μM | Tank et al. (1981) |
Unknown | MC ALDH | R Liver | Microsomes | 450 μM | Tank et al. (1981) |
Unknown | ALDH-II | H Brain | Cytosol, mitochondria | MT 2 mM; C 2 mM | Hafer et al. (1987) |
Unknown | High-affinity ALDH | T Brain | Cytosol, mitochondria | 3.7 μMd | Nilsson (1988) |
Unknown | Low-affinity ALDH | T Brain | Cytosol, mitochondria | 150 μMc | Nilsson (1988) |
Unknown | ALDH-I and ALDH-II | H brain SN | C, MC, MT, N | N.D. | Agarwal et al. (1982) |
Unknown | ALDH-I | H brain | C, MC, MT | MT 0.3 mM; MC 35 mM C 0.6 mM | Hafer et al. (1987) |
Unknown | Low-affinity ALDH | R Brain | N.D. | 60 μM | Nilsson (1988) |
Unknown | High-affinity ALDH | R Brain | N.D. | 0.5 μM | Nilsson (1988) |
↵ a The source of ALDH protein is abbreviated as follows: human (H), rat (R), or rainbow trout (T)
↵ b The subcellular location of DOPAL-oxidizing activity is abbreviated as follows: N.D., not detected; MT, mitochondrial; MC, microsomal; C, cytosolic; MX, mitochondrial matrix; MB, mitochondrial, membrane-bound; N, nucleus
↵ c Recombinant purified protein
↵ d A Km was given, but it was unclear as to which subcellular compartment it referred to