Nicorandil | Donates NO, which once applied exogenously can protect the heart against ischemia/reperfusion injury | Gomma et al. (2001) |
Diazoxide | Suppresses mitochondrial respiration and increases formation of free oxygen radicals independent of the potassium concentration, an effect being blocked by 5-HD; inhibits succinate dehydrogenase; reduces infarct size which is blocked by L-NAME, implying a nitric oxide synthase-dependent effect | Minners et al. (2007), Dröse et al. (2006), Dröse et al. (2006), Ockaili et al. (1999) |
Diazoxide/Pinacidil | Its uncoupling effect in isolated rat heart mitochondria respiring on pyruvate and malate was markedly reduced by inhibitors of the adenine nucleotide translocase, which also affected mitochondrial matrix volume regulation | Kopustinskiene et al. (2003), Das et al. (2003) |
5-HD | As 5-HD is metabolized in the first 3 steps of the beta-oxidation, its metabolic intermediates, rather than blockade of KATP, could be involved in the inhibitory effect of 5-HD on preconditioning; 5-HD did not affect mitochondrial matrix volume in rat heart mitochondria | Hanley et al. (2003), Das et al. (2003) |