Ligand | Origin | Assay | Potency | Cells (Receptors) | Reference |
---|---|---|---|---|---|
N-formyl-Met-Leu-Phe | E. coli | Chemotaxis | pEC50 = 10.15 | Neutrophils | Showell et al. (1976); Freer et al. (1980) |
Lysozyme release | pEC50 = 7.49 | Neutrophils | Freer et al. (1980) | ||
production | pEC50 = 7.00 | Neutrophils | Boxer et al. (1979) | ||
Binding | pKd = 9.28–7.61 | Neutrophils | Koo et al. (1982) | ||
pKd = 6.37 | Transfected cells (FPR2/ALX) | Quehenberger et al (1993) | |||
N-formyl-Met-Ile-Phe-Leu | S. aureus | Chemotaxis | pEC50 = 7.51 | Monocytes | Rot et al. (1987) |
Competitive binding | pIC50 = 8.01 | Monocytes | Rot et al. (1987) | ||
production | pEC50 = 8.00 | Neutrophils (mFpr1) | Southgate et al. (2008) | ||
N-formyl-Met-Ile-Val-Ile-Leu | L. monocytogenes | Ca2+ flux | pEC50 = 8.66 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 6.80 | HL-60 (FPR2/ALX) | Rabiet et al. (2005) | |||
production | pEC50 = 7.82 | Neutrophils (mFpr1) | Southgate et al. (2008) | ||
N-formyl-Met-Ile-Gly-Trp-Ile | L. monocytogenes | Ca2+ flux | pEC50 = 7.70 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 6.68 | HL-60 (FPR2/ALX) | Rabiet et al. (2005) | |||
N-formyl-Met-Ile-Val-Thr-Leu-Phe | L. monocytogenes | Ca2+ flux | pEC50 = 8.57 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 6.70 | HL-60 (FPR2/ALX) | Rabiet et al. (2005) | |||
N-formyl-Met-Ile-Gly-Trp-Ile-Ile | L. monocytogenes | Ca2+ flux | pEC50 = 7.40 | HL-60 (FPR1) | Rabiet et al. (2005) |
N-formyl-Met-Phy-Glu-Asp-Ala-Val-Ala-Trp-Phy | M. avium | Chemotaxis | pEC50 = 6.00 | CHO (FPR1) | Gripentrog et al. (2008) |
N-formyl-Met-Met-Tyr-Ala-Leu-Phe | Mitochondria, ND6 | Ca2+ flux | pEC50 = 7.92 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 7.82 | HL-60 (FPR2/ALX) | Rabiet et al. (2005) | |||
N-formyl-Met-Leu-Lys-Leu-Ile-Val | Mitochondria, ND4 | Ca2+ flux | pEC50 = 7.92 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 7.26 | HL-60 (FPR2/ALX) | Rabiet et al. (2005) | |||
N-formyl-Met-Tyr-Phe-Ile-Asn-Ile-Leu-Thr-Leu | Mitochondria, ND1 | Binding | pKd = 9.00 | CHO (FPR2/ALX) | Chiang et al. (2000) |
N-formyl-Met-Phe-Ala-Asp-Arg-Trp | Cytochrome c oxidase subunit | Ca2+ flux | pEC50 = 6.80 | HL-60 (FPR1) | Rabiet et al. (2005) |
pEC50 = 6.68 | HL-60 (FPR2/ALX) | Rabiet et al (2005) |
CHO, Chinese hamster ovary; pIC50, negative logarithm of the IC50; pEC50, negative logarithm of the EC50