TABLE 1

Allele frequencies of common variations in different ethnicities Allele frequencies of the indicated variants refer, if not indicated otherwise, to the HapMap data phases II and III (accessed October 2008).

Gene Variation (rs Nomenclature) Common Designation Reference Allele African Americans Sub-Saharan Africans Europeans (North-West Europe) Hispanics Chinese Japanese
ADRA1A rs1048101 R492C = R347C Cys 0.39 0.13–0.28 0.55–0.57 0.423 0.10–0.13 0.15–0.16
ADRA2B rs29000568 del301-303 del 0.12–0.21a 0.31–0.37a
ADRA2C rs61767072 del322-325 del 0.41–0.43b 0.04–0.06b 0.13b
ADRB1 rs1801252 S49G Gly 0.13–0.29c 0.10 0.10–0.15c 0 0–0.13c
ADRB1 rs1801253 R389G Arg 0.59 0.68 0.75 0.85
ADRB2 rs1042713 R16G Gly 0.43 0.46–0.50 0.63–0.68 0.55 0.41–0.44 0.56
ADRB2 rs1042714 Q27E Glu 0.18 0.47 0.12 0.08
ADRB2 rs1800888 I164T Ile 1.0 0.99 1.0 1.0
GNB3 rs5443 C825T C 0.09 0.61 0.66 0.60
GNAS rs7121 T393C T 0.87 0.46 0.69 0.58
GNAS rs6123837 G(–1211)A A 0.08 0.11d 0.5 0.51
ACE rs1799752 I/D I 0.40e 0.46e 0.52e 0.66e
AGT rs699 M235T Thr 0.75 0.85–0.92 0.38–0.42 0.68 0.72–0.79 0.82–0.84
AGT rs4762 T174M Met 0.03 0.03–0.05 0.08–0.14 0.16 0.08–0.144 0.08–0.10
AGTR1 rs5186 A1166C C 0.05 0.25 0.04 0.03

  • Frequencies for variants not represented in HapMap were taken from the following references:

  • ↵ a Small et al. (2001b); Muszkat et al. (2005)

  • ↵ b Small et al. (2002, 2004)

  • ↵ c Brodde (2008); Kirstein and Insel (2004)

  • ↵ d Frey et al. (2008)

  • ↵ e Haiman et al. (2003)