Association of the ADRA2B del301-303 (DD) variant with different cardiovascular and pharmacogenomic phenotypes
| Parameters Analyzed | Results | Reference |
|---|---|---|
| Expression of receptor variants in cell lines | No effect on ligand binding; slightly reduced coupling efficiency to GαS in deletion variant. Markedly reduced receptor phosphorylation and loss of short term desensitization in deletion variant | Small et al., 2001 |
| Hemodynamic epinephrine responses in 16 volunteers | DD associated with blunted epinephrine-induced coronary blood flow increases | Snapir et al., 2003 |
| Vasoconstrictive response to dexmedetomidine in 80 (α2-AR agonist) in 80 surgical patients | DD associated with short lasting vasoconstriction | Talke et al., 2005 |
| Hand vein constriction after azepexole (α2-AR agonist) in 50 healthy volunteers | No effects on investigated parameters | King et al., 2005 |