Association of the GNB3 C825T variant with different cardiovascular and pharmacogenomic phenotypes
| Parameters Analyzed | Results | Reference |
|---|---|---|
| Association study with hypertension; functional analyses of variant | T allele associated with hypertension, occurrence of altered splice variant and increased signal transduction in association with T allele | Siffert et al., 1998 |
| Coronary vasoconstriction in response to α2-AR agonist azepexole in 48 patients with coronary artery disease | T allele, increased coronary blood flow reduction | Baumgart et al., 1999 |
| Coronary vasoconstriction in response to methylergonovine in 131 patients with healthy coronary arteries | T allele, increased susceptibility to vasoconstriction | Meirhaeghe et al., 2001 |
| Hemodynamic parameters in 70 volunteers upon administration of propranolol and α-methylnorepinephrine | T allele, higher stroke volume & lower peripheral resistance; propranolol evokes greater fall in stroke volume. No effect on hand vein constriction. | Schäfers et al., 2001 |
| Effects of endothelin-1, angiotensin II, and norepinephrine on skin microcirculation in 25 volunteers. | T allele, enhanced vasoconstriction to endothelin-1, angiotensin II and norepinephrine | Wenzel et al., 2002 |
| Hemodynamic clonidine responses in 30 young healthy individuals | T allele, greater fall in blood pressure & total peripheral resistance; slowing of pulse wave velocity. | Nürnberger et al., 2003 |
| Interactions of endothelin A receptor antagonist darusentan with endothelin-1, norepinephrine and angiotensin II in 37 volunteers | No effects on systemic or local responses to endothelin A receptor blockade | Mitchell et al., 2004 |
| Interactions of angiotensin II receptor antagonists with endothelin 1, norepinephrine and angiotensin II in 25 volunteers | T allele, more pronounced inhibition by valsartan of angiotensin II- or endothelin 1-mediated vasoconstriction in the microcirculation. | Mitchell et al., 2006 |
| Blood pressure and heart rate response to cold pressure test in 79 healthy subjects | TT genotype: greater positive chronotropic response | Kurnik et al., 2008b |
| Hemodynamic dexmedetomidine responses in 73 healthy subjects | No effects on investigated parameters | Kurnik et al., 2008b |