Association study with hypertension; functional analyses of variant | T allele associated with hypertension, occurrence of altered splice variant and increased signal transduction in association with T allele |
Siffert et al., 1998
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Coronary vasoconstriction in response to α2-AR agonist azepexole in 48 patients with coronary artery disease | T allele, increased coronary blood flow reduction |
Baumgart et al., 1999
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Coronary vasoconstriction in response to methylergonovine in 131 patients with healthy coronary arteries | T allele, increased susceptibility to vasoconstriction |
Meirhaeghe et al., 2001
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Hemodynamic parameters in 70 volunteers upon administration of propranolol and α-methylnorepinephrine | T allele, higher stroke volume & lower peripheral resistance; propranolol evokes greater fall in stroke volume. No effect on hand vein constriction. |
Schäfers et al., 2001
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Effects of endothelin-1, angiotensin II, and norepinephrine on skin microcirculation in 25 volunteers. | T allele, enhanced vasoconstriction to endothelin-1, angiotensin II and norepinephrine |
Wenzel et al., 2002
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Hemodynamic clonidine responses in 30 young healthy individuals | T allele, greater fall in blood pressure & total peripheral resistance; slowing of pulse wave velocity. |
Nürnberger et al., 2003
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Interactions of endothelin A receptor antagonist darusentan with endothelin-1, norepinephrine and angiotensin II in 37 volunteers | No effects on systemic or local responses to endothelin A receptor blockade |
Mitchell et al., 2004
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Interactions of angiotensin II receptor antagonists with endothelin 1, norepinephrine and angiotensin II in 25 volunteers | T allele, more pronounced inhibition by valsartan of angiotensin II- or endothelin 1-mediated vasoconstriction in the microcirculation. |
Mitchell et al., 2006
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Blood pressure and heart rate response to cold pressure test in 79 healthy subjects | TT genotype: greater positive chronotropic response |
Kurnik et al., 2008b
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Hemodynamic dexmedetomidine responses in 73 healthy subjects | No effects on investigated parameters |
Kurnik et al., 2008b
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