TLR2 | Heart/vasculature | Atherosclerosis | Antagonistic |
| Lung | Asthma | Antagonistic |
| Kidney | Ischemia/reperfusion | Antagonistic |
| Pancreas | Diabetes | Antagonistic |
TLR3 | Systemic | Vaccine adjuvant | Agonistic |
| Breast | Anti-cancer | Agonistic |
| Renal system | Anti-cancer | Agonistic |
| Eye | CNV inhibition in AMD | Agonistic |
| Brain | Anti-viral (WNV) | Antagonistic |
TLR4 | Heart/vasculature | Atherosclerosis | Antagonistic |
| Lung | Asthma | Antagonistic |
| Kidney | Ischemia/reperfusion | Antagonistic |
| Pancreas | Diabetes | Antagonistic |
| Joints | Rheumatoid arthritis | Antagonistic |
| Brain | Alzheimer's disease, Parkinson's disease | Antagonistic |
| Systemic | Sepsis | Antagonistic |
| | Vaccine adjuvant | Agonistic |
TLR5 | Hematopoietic system and GI tract | Radio-protective | Agonistic |
| Systemic | Vaccine-adjuvant (influenza virus) | Agonistic |
| GI tract | Treatment of Crohn's disease | Antagonistic |
TLR7/8 | Skin | Treatment of viral induced lesions (caused by papilloma virus and Herpes simplex virus) | Agonistic |
| | Primary tumors | Agonistic |
| | Cutaneous metastases | Agonistic |
| | Anti-viral (HCV) | Agonistic |
| Blood | Chronic lymphocyte leukemia | Agonistic |
| Systemic | SLE | Antagonistic |
TLR9 | Prostate | Anticancer | Agonistic |
| Systemic | Vaccine-adjuvant | Agonistic |
| Systemic | Tumor-vaccine-adjuvant | Agonistic |
| Lung/systemic | Asthma/allergy | Agonistic |