TABLE 3

Summary of reported effects of PPARδ activation in humans

When no arrow is indicated, data were as not reported.

	Sprecher et al., 2007	Risérus et al., 2008	Metabolex, 2008
Subjects
Number	12	6	173
Description	Healthy male lean subjects	Healthy male obese subjects	Overweight or obese subjects with high cholesterol and triglycerides
Agonist	GW501516	GW501516	MBX-8025
Duration	2 weeks	2 weeks	8 weeks
Weight	ND	↓^a
Blood pressure	↔
HDL	↑	↔	↑
LDL		↓	↓
Apo B		↓
Fasting glucose		↓	↓
Fasting insulin		↓	↓
HOMA		↓
Triglycerides	↓	↓	↓
Total cholesterol		↓
Free fatty acids		↓
Liver fat		↓
FGF21		↑^a