Time of Testing (days after CAP) | Desensitization Model | Effects | |||
---|---|---|---|---|---|
Age Group | Species | CAP Dose | Basal Deep Tb | Basal Tsk | |
mg/kg | |||||
1–9 | Adult | Rat | 20–160 | ↑a–d | ↓cd |
10–100 | Adult | Guinea pig | 30–40 | ↑c | — |
Rat | 20–310 | ↕a,c,e | ↕e | ||
↑df | ↑d | ||||
↓bg | ↓b | ||||
Guinea pig | 30–40 | ↕a,c,c | — | ||
Mouse | 45 | ↕dh | — | ||
↑h | |||||
↓h | |||||
60–120 | Neonate | Rat | 50–450 | ↕eil | ↕ek |
↑m | ↑l | ||||
↓j | ↓j,k |
↑, increase; ↓, decrease; ↕, none; —, not studied.
↵a Szolcsányi and Jancsó-Gábor (1973).
↵b Szikszay et al. (1982).
↵c Jancsó-Gábor et al. (1970a).
↵d Székely and Szolcsányi (1979).
↵e Hajós et al. (1983).
↵f Obál et al. (1980).
↵g Obál et al. (1982); Benedek et al. (1983).
↵h Szelényi et al. (2004). In this study, the daily mean deep Tb was unchanged, whereas the mean daytime (light-phase) Tb was decreased, and the mean nighttime (dark-phase) Tb was increased.
↵i Gourine et al. (2001).
↵j Yamashita et al. (2008).
↵k Donnerer and Lembeck (1983).
↵l Hori and Tsuzuki (1981).
↵m Dib (1983).