Discovery and validation of novel genes associated with drug sensitivity using cell-based models
| Drugs | Target Gene | Effect | Ref |
|---|---|---|---|
| AraC | SLC25A37 | ↑ expression leads to ↑ drug sensitivity | Hartford et al., 2009 |
| Daunorubicin | CYP1B1 | ↓ expression leads to ↑ drug sensitivity | Huang et al., 2008b |
| Gemcitabine, AraC | NT5C3 | ↓ expression leads to ↑ sensitivity | Li et al., 2008 |
| Gemcitabine, AraC | FKBP5 | ↓ expression leads to ↓ sensitivity | Li et al., 2008 |
| Carboplatin | CD44 | ↓ expression leads to ↑ sensitivity | Shukla et al., 2009 |
| Azacytidine, Inosine-glycodialdehyde | SLC29A1/ENT1 | Treatment with tight binding inhibitor reduces drug sensitivity | Huang et al., 2004 |
| Paclitaxel, bisantrene, geldanamycin analog, Baker's antifol | ABCB1 | ↓ expression leads to ↑ drug sensitivity | Huang et al., 2004 |
| Camptothecin | ABCB5 | ↓ expression leads to ↑ drug sensitivity | Huang et al., 2004 |