Differential activation of corresponding hypothalamic neurons, brain receptors, and neuroendocrine pathways induced by peripheral effects of ghrelin gene products
| Drugs | Hypothalamic Neuron Activated | Brain Receptors Mediated | Vagal Afferent Dependence |
|---|---|---|---|
| Rat acyl ghrelin | NPY | Y2 and Y4 receptors | Yes |
| Rat des-acyl ghrelin | CRF | CRF2-R | No |
| Rat obestatin | CRF and urocortin 2 | CRF1-R and CRF2-R | Partially |