Effects of acyl ghrelin and obestatin on memory
| Drugs | Animals Studied | Administration Routes with and without Acting Areas | Effects on Memory Retention | Reference |
|---|---|---|---|---|
| Acyl ghrelin | Rats | i.c.v. and microinjected into hippocampus, amygdala, and dorsal raphe nucleus | ↑ Memory retention | Carlini et al., 2002,2004 |
| Acyl ghrelin | Mice | i.c.v. | Reversing decreased memory for novel object recognition in long-term food restriction | Carlini et al., 2008 |
| Acyl ghrelin | Neonatal chicks | i.c.v. | ↓ Memory retention | Carvajal et al., 2009 |
| Obestatin | Rats | i.c.v. | ↑ Memory retention | Carlini et al., 2007b |
i.c.v., intracerebroventricular.