TABLE 6

Effects of acyl ghrelin and obestatin on anxiety behavior

DrugsAnimals StudiedAdministration Routes with and without Acting AreasEffects on AnxietyReference
Acyl ghrelinMicei.c.v. and i.p.↑ Anxiogenic activities in the elevated plus maze testAsakawa et al., 2001a
Acyl ghrelinRatsi.c.v. and microinjected into hippocampus, amygdala, and dorsal raphe nucleus↑ AnxietyCarlini et al., 2002,
Acyl ghrelinNeonatal chicksi.c.v.↑ AnxietyCarvajal et al., 2009
Antisense DNA for acyl ghrelinRatsi.c.v.↑ Anxiolytic effectsKanehisa et al., 2006
ObestatinRatsi.c.v.↑ Memory retentionCarlini et al., 2007b

  • i.c.v., intracerebroventricular; i.p., intraperitoneal.