Effect of withdrawal from long-term benzodiazepine treatment in vivo on GABAA receptor subunit polypeptide expression
| Compound, Species, Dose Duration, Withdrawal Time Brain Region | Subunit mRNA | Reference | |
|---|---|---|---|
| α1 | β3 | ||
| % change | |||
| Flurazepam | |||
| Rat, 100 mg/kg/d, 7 d, 2 d | Tietz et al., 1999b | ||
| Hippocampus | |||
| CA1 | −14SO | N.S. | |
| CA3 | N.S. | +10SO, 9SR | |
| Dentate | N.S. | N.S. | |
| Cerebral cortex | N.S. | ||
| Inferior colliculus | N.S. | ||
| Cerebellum | N.S. | ||
d, day(s); N.S., not significantly different from the control value; SO, stratum oriens; SR, stratum radiatum.