Compound, Species, Dose Duration, Withdrawal Time Brain Region | Subunit mRNA | Reference | |
---|---|---|---|
α1 | β3 | ||
% change | |||
Flurazepam | |||
Rat, 100 mg/kg/d, 7 d, 2 d | Tietz et al., 1999b | ||
Hippocampus | |||
CA1 | −14SO | N.S. | |
CA3 | N.S. | +10SO, 9SR | |
Dentate | N.S. | N.S. | |
Cerebral cortex | N.S. | ||
Inferior colliculus | N.S. | ||
Cerebellum | N.S. |
d, day(s); N.S., not significantly different from the control value; SO, stratum oriens; SR, stratum radiatum.