TABLE 8

Effect of long-term benzodiazepine treatment on GABAA receptor subunit mRNA expression in cultured cells in vitro

Cells, Compound, Concentration, DurationSubunit mRNAReference
α1α3α4α5β1β2β3γ2
% change
Rat hippocampal cells
    Etizolam, 10 μM, 5 dN.S.N.S.N.S.−17−26Sanna et al., 2005
    Lorazepam, 10 μM, 5 d−19+59N.S.N.S.−21Sanna et al., 2005
Rat cerebellar granule cells
    Diazepam, 10 μM, 5 d−20N.S.−24, −26aFollesa et al., 2001a
    Diazepam, 10 μM, 5 d−23N.S.+47−27N.S.−25, −27aFollesa et al., 2002
    Imidazenil, 10 μM, 5 dN.S.N.S.−21, N.S.aFollesa et al., 2001a
    Zaleplon, 10 μM, 5 dN.S.N.S.N.S.N.S.N.S.N.S., N.S.aFollesa et al., 2002
    Zolpidem, 10 μM, 5 dN.S.N.S.N.S.N.S.N.S.N.S., N.S.aFollesa et al., 2002

  • d, day(s); N.S., not significantly different from the control value.

  • ↵a Two values represent S and L splice variants, respectively.